Metabolic syndrome consists of several coexisting conditions, such as high blood pressure, high blood sugar, excess belly fat, nonalcoholic fatty liver disease, and high cholesterol. Collectively these conditions increase the risk of developing heart diseases or type 2 diabetes. We have previously reported that olive oil consumption can aid weight loss and improve heart health. Now, this clinical study in humans provides real-world evidence that nutritional intervention with oleocanthal-rich EVOO can treat metabolic syndrome and reduce the occurrence of future cardiometabolic events.
In this study, 23 men and women with metabolic syndrome and fatty liver disease were given 2 tablespoons (equivalent to about 32 grams of oil) of oleocanthal-rich EVOO, twice daily for 2 months without making additional changes to their lifestyle or eating habits. Metabolic parameters were compared before and after the study for the same study participants, who prior to the study followed a Mediterranean diet consisting of EVOO with standard oleocanthal levels. After supplementing their diet with oleocanthal-rich EVOO for 2 months, participants displayed reduced body weight, waist circumference, BMI, and levels of several pro-inflammatory cytokines. Conversely, the anti-inflammatory cytokine, interleukin-10, was elevated in those that ingested high oleocanthal EVOO, consistent with the anti-inflammatory properties of oleocanthal and EVOO. Altogether, these data indicate that dietary intake of EVOO with high oleocanthal levels improved the metabolic parameters of patients at high risk of developing severe cardiometabolic diseases.
Key Takeaway: Oleocanthal-rich EVOO supplementation for 2 months reduced key markers of metabolic syndrome in humans